Real-world implementation of the INDICAID COVID-19 rapid antigen test

Because the COVID-19 pandemic progresses, there may be an growing want for speedy, accessible assays for SARS-CoV-2 detection. We current a medical analysis and real-world implementation of the INDICAID COVID-19 speedy antigen take a look at (INDICAID speedy take a look at). A multisite medical analysis of the INDICAID speedy take a look at utilizing prospectively collected nasal (bilateral anterior) swab samples from symptomatic topics was carried out.

 

The INDICAID speedy take a look at demonstrated a optimistic % settlement (PPA) and damaging % settlement (NPA) of 85.3% (95% confidence interval [95% CI], 75.6% to 91.6%) and 94.9% (95% CI, 91.6% to 96.9%), respectively, in comparison with laboratory-based reverse transcriptase PCR (RT-PCR) utilizing nasal specimens.

The INDICAID speedy take a look at was then carried out at COVID-19 outbreak screening facilities in Hong Kong as a part of a testing algorithm (termed “dual-track”) to display asymptomatic people for prioritization for confirmatory RT-PCR testing. In a single method, preliminary optimistic INDICAID speedy take a look at outcomes triggered expedited processing for laboratory-based RT-PCR, decreasing the common time to confirmatory end result from 10.85 h to 7.Zero h. In a second method, preliminary optimistic outcomes triggered subsequent testing with an onsite speedy RT-PCR, decreasing the common time to confirmatory end result to 0.84 h.

In 22,994 asymptomatic sufferers, the INDICAID speedy take a look at demonstrated a PPA of 84.2% (95% CI, 69.6% to 92.6%) and an NPA of 99.9% (95% CI, 99.9% to 100%) in comparison with laboratory-based RT-PCR utilizing mixed nasal/oropharyngeal specimens. The INDICAID speedy take a look at has glorious efficiency in comparison with laboratory-based RT-PCR testing and, when utilized in tandem with RT-PCR, reduces the time to confirmatory optimistic end result.

click to read: Human Lactate Dehydrogenase A (LDHA) Protein | abx067672

INDICAID COVID-19 speedy antigen take a look at

IMPORTANCE Laboratory-based RT-PCR, the present gold customary for COVID-19 testing, can require a turnaround time of 24 to 48 h from pattern assortment to end result.

The delayed time to end result limits the effectiveness of centralized RT-PCR testing to cut back transmission and stem potential outbreaks. To deal with this, we performed an intensive analysis of the INDICAID COVID-19 speedy antigen take a look at, a 20-minute speedy antigen take a look at, in each symptomatic and asymptomatic populations. The INDICAID speedy take a look at demonstrated excessive sensitivity and specificity with RT-PCR because the comparator methodology.

A dual-track testing algorithm was additionally evaluated using the INDICAID speedy take a look at to display for preliminary optimistic sufferers, whose samples have been then prioritized for RT-PCR testing. The twin-track methodology demonstrated vital enhancements in expediting the reporting of optimistic RT-PCR take a look at outcomes in comparison with customary RT-PCR testing with out prioritization, providing an improved technique for neighborhood testing and controlling SARS-CoV-2 outbreaks.

Toxoplasma Antigen Rapid Test Card

C11352 Ring Biotechnology Co 15T Ask for price

CPV&CCoV Antigen Rapid Test Card

C11611 Ring Biotechnology Co 10T Ask for price

CPV&CCoV&GIA Antigen Rapid Test Card

C11601 Ring Biotechnology Co 10T Ask for price

SARS-CoV-2 Antigen Rapid Test Kit

CoV2Ag-1 UnScience 1T 9.6 EUR

SARS-CoV-2 Antigen Rapid Test Kit

CoV2Ag-25 UnScience 25T/kit 42 EUR

Rapid Response COVID-19 Saliva Rapid Antigen Test

BSV-COV-2C25B BioServUK 25 tests Ask for price

COVID-19 Antigen Rapid Test Pen (Saliva)

BSV-COV-2PEN20 BioServUK 20 pc Ask for price

NOVATest Antigen Rapid Test Kit (For Single Use) (NOVA Test)

nCov-500-01 Atlas Link Technology 1T 162 EUR

NOVATest Antigen Rapid Kit (NOVA Test)

nCov-500 Atlas Link Technology 20 Tests 162 EUR

GA COVID-19 Rapid Antigen Test

BSV-3980 BioServUK 20 tests Ask for price

SARS-CoV-2 Rapid Antigen Test Nasal

9901-NCOV-03G Roche Diagnostics 25 Tests/Kit 112.8 EUR

Canine Parvovirus Antigen (CPV Ag) Rapid Test Kit

HG001 EnoGene 10 Tests/Kit 16.1 EUR

Human Streptococcus Pneumoniae (SP) Antigen Rapid Test Kit

abx092096-20tests Abbexa 20 tests 477.6 EUR

Canine Coronavirus Antigen (CCV Ag) Rapid Test Kit

HG003 EnoGene 10 Tests/Kit 16.1 EUR

Feline Herpesvirus Antigen (FHV Ag) Rapid Test Kit

HG005 EnoGene 10 Tests/Kit 16.1 EUR

Feline Calicivirus Antigen (FCV Ag) Rapid Test Kit

HG030 EnoGene 10 Tests/Kit 21 EUR

Feline Coronavirus Antigen (FCoV Ag) Rapid Test Kit

HG006 EnoGene 10 Tests/Kit 21 EUR

Avian Influenza Virus Antigen Rapid Test Kit (Colloidal gold)

abx092015-40tests Abbexa 40 tests 518.4 EUR

Coronavirus (SARS-Cov-2) Antigen Rapid Test Device (Saliva)

IOV87952 INVBIO 20T/kit 46.8 EUR

Canine Distemper Virus Antigen (CDV Ag) Rapid Test Kit

HG002 EnoGene 10 Tests/Kit 16.1 EUR

Canine Influenza virus Antigen (CIV Ag) Rapid Test Kit

HG028 EnoGene 10 Tests/Kit 16.1 EUR

Feline Leukemia Virus Antigen (FeLv Ag) Rapid Test Kit

HG029 EnoGene 10 Tests/Kit 21 EUR

Newcastle Disease Virus Antigen Rapid Test Kit (Colloidal gold)

abx092016-40tests Abbexa 40 tests 518.4 EUR

Accu-Tell COVID-19 IgG/IgM Rapid Test

GEN-B352-20tests Accu test 20 tests 283.2 EUR

Accu-Tell COVID-19 IgG/IgM Rapid Test

GEN-B352-40tests Accu test 40 tests 385.2 EUR

Feline Panleukopenia Virus Antigen (FPV Ag) Rapid Test Kit

HG004 EnoGene 10 Tests/Kit 16.1 EUR

Human Chlamydia Trachomatis Antigen Rapid Test Kit (Colloidal gold)

abx092049-20tests Abbexa 20 tests 276 EUR

Avian Influenza H5 Virus Antigen Rapid Test Kit (Colloidal gold)

abx092014-40tests Abbexa 40 tests 585.6 EUR

Avian Influenza H7 Virus Antigen Rapid Test Kit (Colloidal gold)

abx092017-40tests Abbexa 40 tests 518.4 EUR

Healgen Coronavirus Rapid Antigen Test (Professional use)

BSV-GCCOV-502a-20 BioServUK 20 tests Ask for price

The Efficiency of Two Speedy Antigen Checks Throughout Inhabitants-Degree Screening for SARS-CoV-2 An infection

 SARS-CoV-2 antigen assays supply a speedy imply to diagnose and isolate contaminated people. Nonetheless, their utility in population-level screening is unknown.
Aims: The efficiency of two antigen exams in detecting SARS-CoV-2 was assessed amongst people randomly chosen in the neighborhood.
 Examine Design: A potential examine that carried out head-to-head comparability of two SARS-CoV-2 antigen assays. People have been recruited throughout neighborhood SARS-CoV-2 screening over 10 working days. Demographic and medical knowledge have been collected. Normal Q COVID-19 Ag take a look at, a point-of-care chromatographic assay, was performed instantly, after which the pattern was transported to the virology laboratory to carry out PCR and the LIAISON SARS-CoV-2 Ag chemiluminesence immunoassay.
 Outcomes: respiratory samples from 991 people have been collected, and 62 have been optimistic by PCR. Inconclusive PCR outcomes have been noticed in 19 samples and have been excluded. The median age of individuals was 40.2 years (IQR 32.3-47.8), and 932 (94%) have been males. Most (77.4%) of infections have been asymptomatic. The sensitivity and the specificity of the LIAISON assay have been 43.3% (95%CI 30.6-56.8) and 99.9% (95%CI 99.3-100). The Normal Q assay had decrease sensitivity (30.6%, 95%CI 19.6-43.7) however related specificity (98.8%, 95%CI, 97.8-99.4). Equally, the LIAISON assay had larger optimistic predictive worth (96.3%, 95%CI 81-99.9% vs. 63.3%, 95%CI, 43.9-80.1%). Each assays carried out higher in symptomatic sufferers and amongst samples with a low-cycle threshold (Ct < 25).
Conclusion: In our setting of random neighborhood surveillance, speedy antigen testing of nasopharyngeal swabs by both LIAISON SARS-CoV-2 Ag (DiaSorin) or Normal Q COVID-19 Ag (SD Biosensor) was much less delicate to detecting SARS-CoV-2 than the TaqPath COVID-19 RT-PCR.
By Mashid

Leave a Reply

Your email address will not be published. Required fields are marked *

No widgets found. Go to Widget page and add the widget in Offcanvas Sidebar Widget Area.